This FMD (Fasting Mimicking Diet) wiki presents the scientific principles and practical protocol of the 5-day fasting-mimicking program developed by Dr. Valter Longo at the USC Longevity Institute over two decades of cellular biology and aging research. Grounded in peer-reviewed studies published in Cell Metabolism, Cell, and Nature Aging, it explains the physiological benefits: autophagy (recycling of damaged cellular components), ketosis (metabolic conversion of fat to ketone bodies), stem cell rejuvenation, downregulation of aging pathways (IGF-1, mTOR, PKA), improved insulin sensitivity, and reduced chronic inflammation. Enter your bodyweight (kg) to receive personalized daily targets: Day 1 (Transition ~1,100 kcal: 34% carbs, 10% protein, 56% fat), Days 2-5 (Autophagy/Ketosis ~725 kcal: 47% carbs, 9% protein, 44% fat), and Day 6 (Refeeding ~1,400 kcal: gentle plant-based complex carbohydrates). A database of 30+ foods classifies recommended staples (avocado, olive oil, walnuts, macadamia nuts) versus strictly prohibited items (animal proteins, refined sugars, processed carbs). FMD is absolutely contraindicated for pregnant or breastfeeding women, individuals under 18, underweight persons (BMI < 18.5), those with eating disorder history, insulin-dependent diabetics, and patients with severe liver or kidney disease. Consult your physician before starting.

• Day 1 (Transition): ~1,100 kcal | Carbs 34% (~94g) | Protein 10% (~28g) | Fat 56% (~68g)
• Days 2-5 (Autophagy/Ketosis): ~725 kcal | Carbs 47% (~85g) | Protein 9% (~16g) | Fat 44% (~35g)
• Day 6 (Refeeding): ~1,400 kcal | Gentle plant-based complex carbohydrates and broths